Datasets:

ClarusC64
/

pharma-combination-niche-and-stability-mapping-v0.1

id stringclasses 6 values	combination stringclasses 6 values	indication stringclasses 6 values	subgroup_context stringclasses 6 values	dose_context stringclasses 1 value	observed_outcomes stringclasses 6 values	niche_definition stringclasses 6 values	safe_dose_band stringclasses 3 values	relapse_risk_index float64 0.18 0.62	paradox_zone_flags stringclasses 6 values	systemic_resilience_gain float64 0.02 0.72	subgroup_sensitivity stringclasses 6 values	notes stringclasses 6 values	constraints stringclasses 1 value	gold_checklist stringclasses 1 value
NSM-001	SGLT2i + ARNI	HFrEF	older; low BP risk	standard	HF events down; renal stable; dizziness in low BP	cardio_renal_stability_with_BP_guardrail	moderate	0.22	hypotension zone	0.72	low BP subgroup	wide niche with guardrail	Under 260 words	niche+dose+relapse+paradox+gain+sense
NSM-002	PD1i + CTLA4i	melanoma	baseline autoimmunity low	standard	response up; colitis up	anti_tumor_high_gain_high_toxicity	narrow	0.4	immune toxicity zone	0.55	autoimmunity history high risk	niche exists but brittle	Under 260 words	niche+dose+relapse+paradox+gain+sense
NSM-003	metformin + GLP1RA	T2D obesity	GI sensitive	standard	A1c down; weight down; nausea high	metabolic_gain_with_tolerability_limit	moderate	0.18	GI intolerance zone	0.66	GI sensitivity	titrate needed	Under 260 words	niche+dose+relapse+paradox+gain+sense
NSM-004	TNFi + MTX	RA	recurrent infections	standard	CRP down; flares down; infections up	inflammation_control_with_infection_guardrail	moderate	0.28	infection zone	0.6	infection prone	monitoring required	Under 260 words	niche+dose+relapse+paradox+gain+sense
NSM-005	statin + clarithromycin	lipids infection	any	standard	CK up; weakness	no_viable_niche	avoid	0.55	myopathy zone	0.05	all	do not use	Under 260 words	niche+dose+relapse+paradox+gain+sense
NSM-006	warfarin + TMP-SMX	AF infection	elderly	standard	INR spikes; bleed risk	no_viable_niche_without_override_protocol	avoid	0.62	bleed zone	0.02	elderly high risk	requires strict INR protocol	Under 260 words	niche+dose+relapse+paradox+gain+sense

What this dataset tests

Whether a system can map where a combination is safe and stable.

It must produce: niche definition dose band relapse risk paradox zones resilience gain subgroup sensitivity

Required outputs

niche_definition
safe_dose_band
relapse_risk_index
paradox_zone_flags
systemic_resilience_gain
subgroup_sensitivity

Use case

Rational combination design. Guardrails for rollout. Avoid brittle niches.

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