id stringclasses 8
values | condition_family stringclasses 7
values | medication_pair stringclasses 8
values | interaction_axis_candidates stringclasses 8
values | evidence_pack stringclasses 8
values | observed_system_effects stringclasses 8
values | interaction_class stringclasses 3
values | dominant_interaction_axis stringclasses 7
values | net_coherence_effect stringclasses 3
values | safety_or_monitoring_notes stringclasses 8
values | notes stringclasses 8
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SAIM-001 | heart_failure | ACEi + diuretic | hemodynamics; renal; electrolyte | BP improves; edema improves; creatinine stable | Lower congestion with stable renal markers | synergy | hemodynamics | positive | Monitor renal and K early then space out | Guideline-style synergy | Under 240 words. | pair+class+axis+effect |
SAIM-002 | diabetes | metformin + GLP1 | glycemic; appetite; GI tolerance | A1c down; weight down; mild nausea | Multi-axis improvement with tolerable tradeoff | synergy | glycemic | positive | Watch dehydration if nausea severe | Coherence gain case | Under 240 words. | pair+class+axis+effect |
SAIM-003 | diabetes | insulin + sulfonylurea | glycemic; hypoglycemia; adherence | Highs down; frequent lows; variability up | Control with instability | antagonism | glycemic | negative | Deprescribe sulfonylurea; adjust insulin | Classic collision | Under 240 words. | pair+class+axis+effect |
SAIM-004 | psychiatric | SSRI + benzodiazepine | anxiety; sedation; dependence | Anxiety down; sedation up; rebound on missed doses | Short-term relief with fragility | conditional | dependence | mixed | Set taper plan; avoid daily long-term | Depends on duration | Under 240 words. | pair+class+axis+effect |
SAIM-005 | respiratory | ICS + LABA | airway tone; inflammation | Flares down; rescue use down | Aligned control across axes | synergy | airway_control | positive | Monitor technique and adherence | Clean synergy | Under 240 words. | pair+class+axis+effect |
SAIM-006 | cardiac | beta-blocker + stimulant | autonomic; rhythm; BP | Focus up; palpitations up; HR variability up | Push-pull physiology | antagonism | autonomic | negative | Reassess stimulant; monitor HR and BP | Collision axis is autonomic | Under 240 words. | pair+class+axis+effect |
SAIM-007 | pain | opioid + gabapentinoid | CNS; falls; cognition | Pain down; falls up; confusion up | Functional coherence worsens | antagonism | CNS_safety | negative | Fall plan; dose reduction; alternatives | Geriatric risk cluster | Under 240 words. | pair+class+axis+effect |
SAIM-008 | autoimmune | steroid + biologic | immune control; infection risk | Flares down; infection risk up but steroid tapers | Net stability improves with taper | conditional | immune_control | positive | Monitor infection; taper steroid | Depends on taper success | Under 240 words. | pair+class+axis+effect |
What this dataset tests
Whether a medication pair behaves as
- synergy
- neutral stacking
- antagonism
- conditional
Required outputs
- interaction class
- dominant interaction axis
- net coherence effect
- evidence trace
- safety or monitoring notes
Use case
Third layer of the Polypharmacy Coherence Matrix.
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