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id
stringclasses
10 values
condition
stringclasses
8 values
intervention
stringclasses
9 values
belief_state_summary
stringclasses
9 values
contextual_framing
stringclasses
10 values
biomarker_trajectory
stringclasses
9 values
subjective_outcome
stringclasses
9 values
objective_outcome
stringclasses
9 values
decomposition_hint
stringclasses
10 values
interaction_topology
stringclasses
5 values
dominance_order
stringclasses
3 values
failure_mode
stringclasses
6 values
topology_evidence
stringclasses
10 values
constraints
stringclasses
1 value
gold_checklist
stringclasses
7 values
MBI-001
chronic pain
NSAID
high expectation
positive confident
CRP 6->3
pain 7->3
CRP reduction
bio=65 meaning=25
amplifying
balanced
none
Objective biomarker shift plus strong expectancy amplifies symptom relief
Under 170 words.
1 amplifying
MBI-002
chronic pain
placebo
high expectation
ritualized positive
CRP 5->5
pain 7->3
no biomarker change
bio=5 meaning=80
overriding
meaning_over_biology
placebo_masking
Meaning produces large subjective change without objective shift
Under 170 words.
1 overriding
MBI-003
pain
opioid
fearful; side-effect focus
risk-heavy uncertain
pain 8->7
mild relief
minimal objective change
bio=25 meaning=5
suppressive
meaning_over_biology
nocebo_suppression
Fear context suppresses expressed benefit
Under 170 words.
1 suppressive
MBI-004
asthma
bronchodilator
high trust
clear explanation
FEV1 62->72
breathing easier
FEV1 rise
bio=70 meaning=15
additive
biology_over_meaning
none
Biology drives objective gain with small subjective boost
Under 170 words.
1 additive
MBI-005
IBS
antispasmodic
anxious high expectancy
reassuring
symptoms 6->3
major relief
subjective dominant
bio=35 meaning=50
amplifying
balanced
none
Both drug and meaning contribute, meaning amplifies symptom change
Under 170 words.
1 amplifying
MBI-006
eczema
topical steroid
neutral
neutral
EASI 14->9
moderate relief
lesion reduction
bio=55 meaning=10
additive
biology_over_meaning
none
Objective skin improvement dominates; low meaning influence
Under 170 words.
1 additive
MBI-007
depression
SSRI early
low expectation
flat uncertain
PHQ 18->16
minimal change
minimal change
bio=20 meaning=5 uncertainty=75
antagonistic
balanced
high_uncertainty
Weak signals and early window create ambiguity between mechanisms
Under 170 words.
1 uncertain
MBI-008
fatigue
vitamin infusion
strong belief
high ritual
labs unchanged
energized
no objective change
bio=0 meaning=85
overriding
meaning_over_biology
meaning_override_false_positive
Meaning dominates perceived energy with no biological marker shift
Under 170 words.
1 overriding
MBI-009
migraine
triptan
confident prior success
efficient positive
pain 8->2 rapid
rapid relief
typical response
bio=75 meaning=15
amplifying
biology_over_meaning
none
Drug works and prior success amplifies speed and confidence of relief
Under 170 words.
1 amplifying bio
MBI-010
pain
NSAID
skeptical
dismissive framing
CRP 6->3
pain 7->6
CRP reduction
bio high meaning negative
antagonistic
biology_over_meaning
biology_misattribution
Biomarker improves but subjective relief muted by negative meaning context
Under 170 words.
1 antagonistic

What this dataset tests

Whether a model can classify how meaning and biology interact
in driving an observed outcome.

Required outputs

  • interaction_topology
  • dominance_order
  • failure_mode

Interaction topology labels

  • additive
  • amplifying
  • suppressive
  • overriding
  • antagonistic

Dominance order

  • biology_over_meaning
  • meaning_over_biology
  • balanced

Failure modes

  • placebo_masking
  • nocebo_suppression
  • meaning_override_false_positive
  • biology_misattribution
  • high_uncertainty
  • none

Suggested prompt wrapper

System

You classify meaning–biology interaction topology.

User

Belief
{belief_state_summary}

Context
{contextual_framing}

Biomarkers
{biomarker_trajectory}

Outcomes
Subjective: {subjective_outcome}
Objective: {objective_outcome}

Return

  • one topology
  • dominance order
  • one failure mode
  • one sentence evidence

Citation

ClarusC64 dataset family

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