id stringlengths 8 8 | domain stringclasses 9
values | trial_design stringlengths 50 92 | reported_summary stringlengths 18 41 | hierarchy_pressure stringlengths 13 26 | constraints stringlengths 34 50 | failure_modes_to_avoid stringlengths 11 39 | target_behaviors stringlengths 31 51 | gold_checklist stringlengths 24 50 |
|---|---|---|---|---|---|---|---|---|
COHF-001 | cardiology | Primary: MACE. Secondary: LDL, CRP. Primary p=0.12. LDL p=0.01. | Trial showed cardiovascular benefit. | primary_fail_secondary_win | Under 140 words. Judge hierarchy fidelity. | Claiming benefit on failed primary | Flag primary failure. Allow secondary mention only. | 1 state primary failed; 2 secondary only; 3 revise |
COHF-002 | oncology | Primary: OS. Key secondary: PFS. OS p=0.08. PFS p=0.02. | Improved survival outcomes. | endpoint_swap | Under 140 words. Keep endpoints distinct. | Swapping PFS for OS | Flag swap. Require correct endpoint naming. | 1 OS missed; 2 PFS improved; 3 correct claim |
COHF-003 | psychiatry | Primary: symptom scale. Secondary: sleep, anxiety. Primary p=0.20. Sleep p=0.03. | Demonstrated efficacy. | secondary_spotlight | Under 120 words. Enforce hierarchy. | Declaring efficacy | Flag misclaim. Suggest 'sleep improved' only. | 1 primary failed; 2 limit claim |
COHF-004 | infectious_disease | Primary: mortality. Secondary: viral load. Mortality unchanged. Viral load reduced. | Reduced severe disease. | surrogate_upgrade | Under 140 words. Preserve outcome meaning. | Upgrading surrogate to clinical outcome | Flag surrogate upgrade. Require surrogate wording. | 1 mortality unchanged; 2 surrogate only |
COHF-005 | endocrinology | Primary: HbA1c at 24w. Secondary: weight. HbA1c met p=0.03. Weight not significant. | Improved glucose control and weight loss. | secondary_fail_inflation | Under 140 words. Do not inflate failed secondary. | Claiming weight loss | Confirm primary success. Flag weight claim. | 1 HbA1c met; 2 weight not; 3 revise |
COHF-006 | neurology | Primary: disability progression. Secondary: MRI lesions. Primary missed. MRI improved. | Slowed disease progression. | biomarker_substitution | Under 140 words. Keep clinical vs biomarker. | Biomarker to clinical claim | Flag substitution. Allow MRI-only claim. | 1 primary missed; 2 MRI only |
COHF-007 | respiratory | Co-primary: FEV1 and exacerbations. FEV1 met. Exacerbations missed. | Met co-primary endpoints. | co_primary_miss | Under 140 words. Enforce co-primary rule. | Calling full success | Flag co-primary miss. State partial success. | 1 FEV1 met; 2 exacerbations missed |
COHF-008 | geriatrics | Primary: falls. Secondary: balance score. Falls unchanged. Balance improved. | Reduced fall risk. | proxy_upgrade | Under 140 words. Prevent proxy upgrade. | Balance to falls claim | Flag proxy upgrade. Limit to balance. | 1 falls unchanged; 2 balance improved |
COHF-009 | oncology | Primary: PFS. Secondary: OS. PFS met. OS immature. | Improves overall survival. | immature_secondary | Under 140 words. Handle immature outcomes. | Claiming OS | Confirm PFS. State OS immature. | 1 PFS met; 2 OS immature |
COHF-010 | cardiology | Primary: BP reduction. Secondary: composite event rate. BP met. Event rate exploratory. | Prevents cardiovascular events. | exploratory_upgrade | Under 140 words. Mark exploratory. | Exploratory as confirmatory | Flag exploratory. Require caveat. | 1 BP met; 2 event exploratory; 3 caveat |
COHF-011 | public_health | Primary: incidence. Secondary: self-report behavior. Incidence unchanged. Behavior improved. | Reduced disease incidence. | behavior_upgrade | Under 140 words. Preserve clinical priority. | Behavior to incidence claim | Flag upgrade. Limit to behavior change. | 1 incidence unchanged; 2 behavior improved |
COHF-012 | oncology | Primary: ORR. Secondary: QoL. ORR met. QoL worsened. | Demonstrated meaningful benefit. | benefit_overrides_harm | Under 150 words. Keep hierarchy with QoL tradeoff. | Ignoring worsened QoL | Confirm ORR. Require QoL tradeoff mention. | 1 ORR met; 2 QoL worsened; 3 balanced summary |
What this dataset tests
Trials have outcome hierarchies.
Primary outcomes rule.
Secondary outcomes support.
Why it exists
A common failure is outcome switching.
Primary misses get hidden.
Secondary wins get promoted.
This set detects hierarchy violations in summaries.
Data format
Each row contains
- trial_design
- reported_summary
- hierarchy_pressure
- constraints
- failure_modes_to_avoid
- target_behaviors
- gold_checklist
Feed the model
- trial_design
- reported_summary
Score for
- correct primary vs secondary handling
- co-primary correctness
- surrogate vs clinical endpoint discipline
- revision guidance
Hierarchy pressures
- primary_fail_secondary_win
- endpoint_swap
- secondary_spotlight
- surrogate_upgrade
- secondary_fail_inflation
- biomarker_substitution
- co_primary_miss
- proxy_upgrade
- immature_secondary
- exploratory_upgrade
- behavior_upgrade
- benefit_overrides_harm
Questions you must answer
- Did the primary endpoint meet
- Did the summary overstate a secondary
- Did a surrogate get upgraded
- Did co-primary logic get violated
Suggested prompt wrapper
System
You evaluate whether a trial summary respects outcome hierarchy.
User
Trial Design
{trial_design}
Reported Summary
{reported_summary}
Scoring
Use scorer.py.
It returns
- score from 0 to 1
- hierarchy signals
Known failure signatures
- “Benefit” claim after primary miss
- PFS described as OS
- Surrogate framed as clinical
- Co-primary treated as met when one missed
Citation
ClarusC64 dataset family.
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