| --- |
| language: |
| - en |
| license: mit |
| pretty_name: AlphaFold Interface Coherence Baseline Mapping v0.1 |
| dataset_name: alphafold-interface-coherence-baseline-mapping-v0.1 |
| tags: |
| - clarusc64 |
| - alphafold |
| - alphafold-multimer |
| - protein-protein-interactions |
| - interface-stability |
| task_categories: |
| - tabular-regression |
| size_categories: |
| - 1K<n<10K |
| configs: |
| - config_name: default |
| data_files: |
| - split: train |
| path: data/train.csv |
| - split: test |
| path: data/test.csv |
| --- |
| |
| ## What this dataset tests |
|
|
| Whether a model can construct |
| a stable baseline map |
| of protein–protein interface coherence. |
|
|
| This is the intact coupling state. |
| No stress applied. |
| No mutation applied. |
|
|
| The target is the interface basin. |
|
|
| ## Inputs |
|
|
| interface_residue_count |
| contact_density |
| baseline_deltaG_bind |
| baseline_kd_nM |
| contact_stability_score |
| hotspot_integrity_score |
| allosteric_cross_interface_score |
|
|
| ## Required outputs |
|
|
| interface_coherence_score |
| signal_paths |
| baseline_failure_margin |
| |
| ## Task |
| |
| Given baseline interface metrics |
| predict: |
| |
| - interface coherence score |
| - cross-interface signal paths |
| - the failure margin before instability |
| |
| ## Use cases |
| |
| Biologic complex design |
| Synthetic pathway assembly |
| Protein engineering QC |
| Baseline maps for stress testing |
| |
