data/train.csv

id,pair_id,domain_a,domain_b,source_mechanism,proposed_analogue,invariant_mapping,invalid_transfer_risks,confounder_list,minimal_validation_plan,transfer_confidence_0_100,stress_test_evidence,constraints,gold_checklist
TVST-001,"P-01","fibrosis prevention in wound healing","PTSD prevention after trauma","early inflammatory dampening reduces myofibroblast persistence and scar rigidity","early hyperarousal dampening reduces rigid memory consolidation and chronic PTSD","amplification→hardening; persistent activation→rigid remodeling","analogy fails if trauma exposure continues; psychological hardening may arise without arousal overshoot; intervention timing window may differ","social support, prior trauma load, substance use, sleep deprivation","RCT or matched cohort: early arousal-dampening protocol within 72h vs control; outcomes PTSD severity at 3 and 6 months; mediators sleep and arousal markers","78","Both have early amplification and later remodeling, but Domain B has strong context drivers and measurement noise","Under 260 words.","risks+confounders+plan+confidence"
TVST-002,"P-02","immune tolerance induction in allergy","phobia exposure therapy","graded antigen exposure retrains immune response toward tolerance","graded exposure retrains threat prediction toward safety","graded exposure schedule; reactivity recalibration","fear extinction is context-bound and can return; immune tolerance may be more durable; patient dropout alters trajectory","therapist quality, avoidance severity, comorbid depression, medication changes","Minimal test: compare graded vs massed exposure schedule; measure relapse at 1, 3, 6 months; track context generalization tasks","74","Transfer holds at schedule level but durability properties differ between domains","Under 260 words.","risks+confounders+plan+confidence"
TVST-003,"P-03","asthma rescue window dynamics","panic attack rescue window dynamics","early bronchodilation interrupts bronchospasm positive feedback","early grounding interrupts autonomic arousal positive feedback","positive feedback loop; early interruption window","panic triggers can be internal and self-sustaining; asthma triggers often external; grounding may not change physiology in severe panic","caffeine, sleep loss, interoceptive sensitivity, respiratory alkalosis","Minimal test: time-to-intervention vs symptom duration; randomized prompt to grounding within 2 minutes vs later; outcome recurrence over 4 weeks","76","Loop structure maps, but trigger source and physiology coupling differ","Under 260 words.","risks+confounders+plan+confidence"
TVST-004,"P-04","microbiome recolonization after antibiotics","sleep rhythm restoration after burnout","guided recolonization restores stable gut ecosystem","guided re-entrainment restores stable circadian rhythm","attractor restoration; stability through repeated inputs","sleep is strongly shaped by environment and intent; microbiome shaped by ecology; analogy fails if burnout includes psychiatric comorbidity","light exposure, work schedule, depression, alcohol","Minimal test: fixed wake time + morning light vs control; measure sleep regularity and fatigue; compare to microbiome stability metric conceptually","68","Shared attractor idea is valid but intervention levers differ in controllability","Under 260 words.","risks+confounders+plan+confidence"
TVST-005,"P-05","stroke motor rehab learned nonuse","aphasia language relearning compensatory avoidance","constraint-induced therapy prevents learned nonuse","forced language use prevents compensatory shortcuts","plasticity requires forced engagement; avoid compensation","language has social cost and fatigue; forced use may reduce participation; plateau meanings differ","caregiver support, education, depression, aphasia severity","Minimal test: intensive practice block vs standard; measure functional language and participation at 4 and 12 weeks; track fatigue and dropout","72","Plasticity mapping holds, but compliance pressure and social constraints are stronger in language","Under 260 words.","risks+confounders+plan+confidence"
TVST-006,"P-06","sepsis early stabilization bundle","delirium prevention bundle","early multi-stream stabilization prevents cascade collapse","early environment and sleep stabilization prevents cognitive collapse","restore coupling across streams early","delirium has multiple etiologies; sedation confounds; measurement of coherence is noisier","medication burden, ICU noise, baseline cognition, infection severity","Minimal test: bundle vs usual care; delirium incidence and duration; mediators sleep metrics and light/noise logs","77","The bundle concept transfers, but causality in delirium is less direct and confounded by drugs","Under 260 words.","risks+confounders+plan+confidence"
TVST-007,"P-07","bone callus scaffolding","habit scaffolding in behavior change","temporary scaffold supports remodeling then removal","temporary routine supports habit formation then autonomy","scaffold then remodel then remove","habits depend on meaning and social context; scaffold removal timing is subjective","life stress, social support, motivation, rewards","Minimal test: time-limited scaffold routine vs indefinite scaffold; outcomes habit persistence at 3 months; measure stress and context change","70","Structure transfer is plausible but control variables differ and measurement is subjective","Under 260 words.","risks+confounders+plan+confidence"
TVST-008,"P-08","central sensitization in chronic pain","threat sensitization in chronic anxiety","learning-based amplification converts transient signals into persistent prediction loops","learning-based amplification converts transient stress into persistent threat prediction","prediction bias loop; reinforcement maintains state","pain can have ongoing peripheral drivers; anxiety can persist without external driver; interventions differ","sleep, trauma history, medication, ongoing injury","Minimal test: measure prediction bias markers before and after intervention; compare pain vs anxiety cohorts; outcome symptom persistence and generalization","73","Loop concept transfers, but presence of peripheral drivers can break symmetry","Under 260 words.","risks+confounders+plan+confidence"
TVST-009,"P-09","tolerance induction via graded exposure","panic disorder interoceptive exposure","graded exposure builds tolerance","graded interoceptive exposure reduces panic reactivity","graded exposure invariant","panic physiology and catastrophizing can overpower exposure; dropout bias","therapist skill, comorbidity, medication","Minimal test: graded schedule vs random exposure; outcomes panic frequency and avoidance; track dropout","71","Transfer is plausible but adherence and cognition confound effect size","Under 260 words.","risks+confounders+plan+confidence"
TVST-010,"P-10","plateau interpretation in stroke rehab","plateau interpretation in aphasia rehab","plateau may signal consolidation or stalled adaptation","plateau may signal consolidation or stalled adaptation","plateau semantics invariant","plateaus measured differently; language gains appear in bursts; measurement instruments differ","testing frequency, practice quality, fatigue","Minimal test: classify plateau segments and compare outcomes after protocol change vs hold; measure later gains and relapse","69","Concept transfers but measurement mismatch is the main risk","Under 260 words.","risks+confounders+plan+confidence"